Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 15/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19225412 | 0.91 | MAOA (0.34) | PLA2G7SIGMAR1DRD4MAOBF9 | |
| SCHEMBL15901188 | 0.88 | PLA2G7 (0.44) | PLA2G7MAOB | |
| SCHEMBL19225227 | 0.86 | PLA2G7 (0.32) | PLA2G7MAOB | |
| SCHEMBL15900990 | 0.80 | PLA2G7 (0.42) | PLA2G7 | |
| SCHEMBL16775593 | 0.78 | GRM5 (0.39) | PLA2G7MAOB | |
| SCHEMBL15901142 | 0.73 | PLA2G7 (0.39) | PLA2G7 | |
| SCHEMBL15920489 | 0.72 | PLA2G7 (0.43) | PLA2G7 | |
| SCHEMBL15901311 | 0.72 | PLA2G7 (0.49) | PLA2G7 | |
| SCHEMBL15900997 | 0.72 | PLA2G7 (0.49) | PLA2G7 | |
| SCHEMBL14670123 | 0.72 | PLA2G7 (0.48) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948452-B1 | 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-08-09 | — | — | EP | disclosed |