Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
| ▸ | CTSB | P07858 | 4/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776475 | 0.76 | SGMS2 (0.37) | TSHRKDM4EPOLBSGMS2MAOB | |
| SCHEMBL3301730 | 0.76 | TSHR (0.50) | TSHRKDM4EPOLBSGMS2MAOB | |
| SCHEMBL3338802 | 0.76 | TSHR (0.50) | TSHRKDM4EPOLBSGMS2MAOB | |
| SCHEMBL19225502 | 0.75 | CTSS (0.37) | TSHRKDM4EPOLBSGMS2MAOB | |
| SCHEMBL5529079 | 0.73 | KDM4E (0.53) | TSHRKDM4EPOLBSGMS2MAOB | |
| SCHEMBL6043011 | 0.71 | TSHR (0.58) | TSHRKDM4EPOLBTACR1ALDH1A1 | |
| SCHEMBL20267540 | 0.70 | TSHR (0.47) | TSHRKDM4EPOLBSGMS2MAOB | |
| SCHEMBL3474055 | 0.70 | TSHR (0.56) | TSHRKDM4EPOLBTACR1ALDH1A1 | |
| SCHEMBL19225650 | 0.70 | KDM4E (0.42) | TSHRKDM4EPOLBTACR1ALDH1A1 | |
| SCHEMBL1691827 | 0.69 | TSHR (0.61) | TSHRKDM4EPOLBTACR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928867-B1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | HOFFMANN LA ROCHE (CH) | 2017-08-09 | — | — | EP | disclosed |