Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 5/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16084954 | 0.85 | RIPK1 (0.70) | RIPK1RIPK2RIPK3TNF | |
| SCHEMBL16085003 | 0.84 | RIPK1 (0.62) | RIPK1RIPK2RIPK3TNF | |
| SCHEMBL16084985 | 0.76 | RIPK1 (0.63) | RIPK1RIPK2RIPK3TNFABL1 | |
| SCHEMBL19225593 | 0.75 | RIPK1 (0.48) | RIPK1RIPK2RIPK3TNFABL1 | |
| SCHEMBL16084949 | 0.72 | RIPK1 (0.79) | RIPK1RIPK2RIPK3TNFABL1 | |
| SCHEMBL16084948 | 0.72 | RIPK1 (0.79) | RIPK1RIPK2RIPK3TNFABL1 | |
| SCHEMBL16084958 | 0.72 | RIPK1 (0.92) | RIPK1RIPK2RIPK3TNFABL1 | |
| SCHEMBL16084969 | 0.71 | RIPK1 (0.75) | RIPK1RIPK2RIPK3ABL1CYP3A4 | |
| SCHEMBL17471719 | 0.71 | RIPK1 (0.99) | RIPK1RIPK2RIPK3TNFABL1 | |
| SCHEMBL16084944 | 0.71 | RIPK1 (0.90) | RIPK1RIPK2RIPK3TNFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725452-B2 | Substituted indoles and pyrroles as RIP kinase inhibitors | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-08 | — | — | US | disclosed |