Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.41 |
| ▸ | TNF | P01375 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.31 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.31 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16084951 | 0.91 | RIPK1 (0.59) | RIPK1RIPK2RIPK3ABL1TNF | |
| SCHEMBL16084957 | 0.87 | RIPK1 (0.61) | RIPK1RIPK2RIPK3ABL1TNF | |
| SCHEMBL17471697 | 0.85 | RIPK1 (0.45) | RIPK1RIPK2RIPK3ABL1MAPT | |
| SCHEMBL16084980 | 0.80 | RIPK1 (0.49) | RIPK1RIPK2RIPK3TNFMAPT | |
| SCHEMBL16084969 | 0.77 | RIPK1 (0.75) | RIPK1RIPK2RIPK3ABL1CYP3A4 | |
| SCHEMBL16084961 | 0.76 | RIPK1 (0.55) | RIPK1RIPK2RIPK3ABL1TNF | |
| SCHEMBL16085012 | 0.76 | RIPK1 (0.55) | RIPK1RIPK2RIPK3ABL1TNF | |
| SCHEMBL16084943 | 0.76 | RIPK1 (0.75) | RIPK1RIPK2RIPK3ABL1TNF | |
| SCHEMBL19225534 | 0.75 | RIPK1 (0.58) | RIPK1RIPK2RIPK3ABL1CYP3A4 | |
| SCHEMBL19225532 | 0.75 | RIPK1 (0.55) | RIPK1RIPK2RIPK3ABL1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725452-B2 | Substituted indoles and pyrroles as RIP kinase inhibitors | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-08 | — | — | US | disclosed |