Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757099 | 0.86 | HTT (0.55) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL8397291 | 0.85 | NPC1 (0.47) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL1922400 | 0.83 | NPC1 (0.57) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL27508922 | 0.83 | HTT (0.56) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL1922100 | 0.83 | HTT (0.52) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL1922880 | 0.82 | JAK2 (0.49) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL5641091 | 0.82 | NPC1 (0.45) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL2990374 | 0.81 | HTT (0.50) | HTTNPC1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL4488614 | 0.80 | HTT (0.50) | HTTNPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL5748247 | 0.80 | MAPT (0.58) | HTTRAB9AALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531510-B1 | PYRAZOLO[5,1B]OXAZOLE DERIVATIVES AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2014-07-23 | — | — | EP | disclosed |
| EP-2531510-A1 | PYRAZOLO[5,1B]OXAZOLE DERIVATIVES AS CRF-1 RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-20120295942-A1 | Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists | NOVARTIS AG (CH) | 2012-11-22 | — | — | US | disclosed |
| US-8163785-B2 | Pyrazolo[5,1b]oxazole derivatives as CRF-1 receptor antagonists | NOVARTIS AG (CH) | 2012-04-24 | — | — | US | disclosed |
| US-7994203-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-09 | — | — | US | disclosed |
| US-20110190360-A1 | PYRAZOLO[5,1B]OXAZOLE DERIVATIVES AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-04 | — | — | US | disclosed |
| WO-2011092290-A1 | PYRAZOLO[5,1B]OXAZOLE DERIVATIVES AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-04 | — | — | WO | disclosed |
| EP-2328902-A1 | PYRAZOLO [5,1-B]OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | Novartis AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010015628-A1 | PYRAZOLO [5,1-B] OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |
| US-20100035874-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-02-11 | — | — | US | disclosed |
| EP-0889938-A1 | FOOD GRADE JET INKS | VIDEOJET SYSTEMS INTERNATIONAL, INC. (US) | 1999-01-13 | — | — | EP | disclosed |
| US-5821255-A | REGULATING THE SECRETION OF CORTICOTROPIN, BETA-ENDORPHIN OR PEPTIDES DERIVED FROM PROOPIOMELANOCORTIN | SANOFI (FR) | 1998-10-13 | — | — | US | disclosed |
| EP-0659747-B1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-04-01 | — | — | EP | disclosed |
| WO-1997035933-A1 | FOOD GRADE JET INKS | VIDEOJET SYSTEMS INTERNATIONAL, INC. (US) | 1997-10-02 | — | — | WO | disclosed |
| CN-1127252-A | Branched-amino-sbustituted thiazoles, processes for their preparation and the pharmaceutical compositions which contain them | SANOFI SA (FR) | 1996-07-24 | — | — | CN | disclosed |
| EP-0659747-A1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-06-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035874-A1 | Organic compounds | CRH, CRHR1, CRHR2 | HTT 3587/4885NPC1 1952/4885RAB9A 3388/4885 |
| US-20110190360-A1 | PYRAZOLO[5,1B]OXAZOLE DERIVATIVES AS CRF-1 RECEPTOR ANTAGONISTS | CRHR1, CRH, CRHR2 | HTT 4621/4885NPC1 2083/4885RAB9A 2711/4885 |
| US-20120295942-A1 | Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists | CRHR1, CRH, CRHR2 | HTT 4272/4885NPC1 1959/4885RAB9A 3086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.