Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29392677 | 0.84 | CYP3A4 (0.62) | CYP3A4MTNR1BMTNR1AHSD17B10MEN1 | |
| SCHEMBL267732 | 0.84 | CYP3A4 (0.62) | CYP3A4MTNR1BMTNR1AHSD17B10MEN1 | |
| SCHEMBL13634449 | 0.83 | L3MBTL1 (0.51) | MTNR1BMTNR1AHSD17B10HDAC8ALDH1A1 | |
| SCHEMBL14150184 | 0.77 | TPH1 (0.41) | CYP3A4HSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL23229241 | 0.77 | HSD17B10 (0.59) | MTNR1BMTNR1AHSD17B10MEN1KMT2A | |
| SCHEMBL11769915 | 0.76 | TP53 (0.47) | CYP3A4HSD17B10MEN1KMT2AHDAC8 | |
| SCHEMBL9563461 | 0.75 | CYP3A4 (0.44) | CYP3A4MTNR1BMTNR1AHSD17B10MEN1 | |
| SCHEMBL2257736 | 0.75 | SMN1; SMN2 (0.49) | CYP3A4MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL5743959 | 0.74 | HSD17B10 (0.75) | CYP3A4MTNR1BMTNR1AHSD17B10MEN1 | |
| SCHEMBL1922374 | 0.74 | CYP3A4 (0.49) | CYP3A4HSD17B10MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328902-A1 | PYRAZOLO [5,1-B]OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | Novartis AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010015628-A1 | PYRAZOLO [5,1-B] OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |