Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 5/20 | 0.49 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26051105 | 0.85 | CBFB (0.40) | CBFBRUNX1METAP2METAP1NPC1 | |
| SCHEMBL19228826 | 0.84 | ALOX5 (0.46) | CBFBRUNX1ALOX5EPHX2FGFR1 | |
| SCHEMBL12419209 | 0.77 | RAB9A (0.46) | NPC1RAB9APKMTP53MAPT | |
| SCHEMBL19228812 | 0.76 | RUNX1 (0.56) | CBFBRUNX1METAP2METAP1NPC1 | |
| SCHEMBL19228816 | 0.74 | CBFB (0.45) | CBFBRUNX1ALOX5EPHX2AMY1A | |
| SCHEMBL125165 | 0.73 | CBFB (0.83) | CBFBRUNX1AMY1ACDK4CCNA2 | |
| SCHEMBL17268719 | 0.72 | ALOX5 (0.40) | CBFBALOX5EPHX2AMY1ACDK4 | |
| SCHEMBL26051103 | 0.72 | CBFB (0.41) | CBFBRUNX1METAP2METAP1NPC1 | |
| SCHEMBL125119 | 0.71 | CBFB (0.49) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL1171203 | 0.70 | NPC1 (0.51) | CBFBALOX5EPHX2METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170233375-A1 | CANCER THERAPEUTICS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233375-A1 | CANCER THERAPEUTICS | RUNX1, CBFB, MCL1 | CBFB 2/4885RUNX1 1/4885ALOX5 2686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.