Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 4/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 6/20 | 0.38 |
| ▸ | SI | P14410 | 6/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 6/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124235 | 0.72 | CBFB (0.68) | CBFBCCR1CCR8ADORA3ADORA1 | |
| SCHEMBL29484635 | 0.71 | NPC1 (0.60) | CCR1CCR8METAP2METAP1ADORA3 | |
| SCHEMBL11570157 | 0.71 | NPC1 (0.60) | CCR1CCR8METAP2METAP1ADORA3 | |
| SCHEMBL34717 | 0.71 | NPC1 (0.49) | CBFBCCR1CCR8METAP2METAP1 | |
| SCHEMBL21976942 | 0.71 | METAP2 (0.67) | CBFBMETAP2METAP1GAAMEN1 | |
| SCHEMBL2578465 | 0.70 | CBFB (0.73) | CBFBADORA3ADORA1ADORA2AESR1 | |
| SCHEMBL13286842 | 0.70 | NPC1 (0.48) | CBFBCCR1CCR8METAP2METAP1 | |
| SCHEMBL17525993 | 0.69 | CBFB (0.51) | CBFBCCR1CCR8GAAMGAM | |
| SCHEMBL13135757 | 0.69 | HTT (0.50) | ADORA3MEN1POLBKMT2A | |
| SCHEMBL6805347 | 0.69 | PARP1 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170233375-A1 | CANCER THERAPEUTICS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233375-A1 | CANCER THERAPEUTICS | RUNX1, CBFB, MCL1 | CBFB 2/4885CCR1 874/4885CCR8 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.