Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | P4HB | P07237 | 5/20 | 0.41 |
| ▸ | SMAD3 | P84022 | 4/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923168 | 0.74 | CYP11B2 (0.38) | MAPTNPC1RAB9AALDH1A1PIK3CA | |
| SCHEMBL1923039 | 0.74 | MAPT (0.43) | MAPTNPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL14105031 | 0.69 | HSP90AA1 (0.64) | MAPTGAAALDH1A1 | |
| SCHEMBL19500868 | 0.68 | MAPT (0.59) | MAPTNPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL12255510 | 0.65 | MAPT (0.56) | MAPTNPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL24434308 | 0.64 | CYP3A4 (0.56) | MAPTNPC1RAB9AP4HBSMAD3 | |
| SCHEMBL1305116 | 0.63 | BRD9 (0.44) | MAPTNPC1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL12128810 | 0.62 | MAPT (0.62) | MAPTNPC1RAB9AGAAL3MBTL1 | |
| SCHEMBL9093746 | 0.62 | LMNA (0.71) | MAPTNPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL11791151 | 0.62 | PRKDC (0.65) | MAPTNPC1RAB9AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328893-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corp. (US) | 2011-06-08 | — | — | EP | claimed |
| WO-2010017479-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2010-02-11 | — | — | WO | claimed |