Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL31278552 | 0.92 | GAA (0.39) | GAAGFERPDE4DPOLBBRD4 | |
| SCHEMBL15660193 | 0.83 | PDE4D (0.41) | GAAGFERPDE4DBRD4LMNA | |
| SCHEMBL15777023 | 0.80 | PDE4D (0.57) | GAAPDE4DPOLBCSNK2A2KDR | |
| SCHEMBL11547466 | 0.77 | GAA (0.41) | GAAGFERPOLBPDPK1ALDH1A1 | |
| SCHEMBL17397805 | 0.77 | PDE4D (0.40) | PDE4DPOLBCSNK2A2KDRCSNK2B | |
| SCHEMBL2324059 | 0.75 | PDE4D (0.71) | GAAPDE4DPOLBLMNAMEN1 | |
| SCHEMBL3749392 | 0.74 | PDPK1 (0.46) | GAAGFERPOLBPDPK1L3MBTL1 | |
| SCHEMBL3804253 | 0.74 | GAA (0.40) | GAAGFERPDE4DPOLBPDPK1 | |
| SCHEMBL30120920 | 0.74 | PDE4D (0.42) | PDE4DPOLBCSNK2A2KDRCSNK2B | |
| SCHEMBL4748623 | 0.74 | PDE4D (0.42) | GAAGFERPDE4DLMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174696-A1 | 2,8-DIAZASPIRO[4.5]DECANE COMPOUNDS | GENENTECH, INC. (US) | 2024-05-30 | — | — | US | disclosed |
| EP-4347594-A1 | 2, 8-DIAZASPIRO [4.5] DECANE COMPOUNDS | Genentech, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117425654-A | 2, 8-diazaspiro [4.5] decane compounds | 基因泰克公司 | 2024-01-19 | — | — | CN | disclosed |
| WO-2022253341-A1 | 2, 8-DIAZASPIRO [4.5] DECANE COMPOUNDS | GENENTECH, INC. (US) | 2022-12-08 | — | — | WO | disclosed |
| US-10005782-B2 | Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators | BEIGENE, LTD. (KY) | 2018-06-26 | — | — | US | disclosed |
| US-20170073349-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | BEIGENE, LTD. (KY) | 2017-03-16 | — | — | US | disclosed |
| EP-3141546-A1 | INHIBITOR OF BRUTON'S TYROSINE KINASE | Centaurus Biopharma Co., Ltd. (CN) | 2017-03-15 | — | — | EP | disclosed |
| US-9556188-B2 | Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulators | BEIGENE, LTD. (KY) | 2017-01-31 | — | — | US | disclosed |
| US-9447106-B2 | Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators | BEIGENE, LTD. (KY) | 2016-09-20 | — | — | US | disclosed |
| US-20160083392-A1 | Fused heterocyclic compounds as protein kinase inhibitors | BEIGENE, LTD. (KY) | 2016-03-24 | — | — | US | disclosed |
| US-7968554-B2 | Pyrazolo[3,4-d]pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968554-B2 | Pyrazolo[3,4-d]pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-28 | — | — | US | disclosed |
| EP-2188290-B1 | PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | disclosed |
| EP-2188290-B1 | PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | disclosed |
| US-20100089285-A1 | COLORANT COMPOUND AND INK INCLUDING THE COLORANT COMPOUND | CANON KABUSHIKI KAISHA (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100089285-A1 | COLORANT COMPOUND AND INK INCLUDING THE COLORANT COMPOUND | CANON KABUSHIKI KAISHA (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2123654-A1 | PYRAZOLOPYRIMIDINE COMPOUND | Taisho Pharmaceutical Co. Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BARTKOVITZ DAVID JOSEPH | 2009-02-19 | — | — | US | disclosed |
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BARTKOVITZ DAVID JOSEPH | 2009-02-19 | — | — | US | disclosed |
| WO-2009021869-A1 | PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BRAF, RAF1, PRKDC | GAA 4242/4885GFER 4342/4885PDE4D 352/4885 |
| US-20100089285-A1 | COLORANT COMPOUND AND INK INCLUDING THE COLORANT COMPOUND | TYR, CCNL2, RB1 | GAA 2923/4885GFER 547/4885PDE4D 4031/4885 |
| US-20240174696-A1 | 2,8-DIAZASPIRO[4.5]DECANE COMPOUNDS | LATS1, LATS2, GLS2 | GAA 3193/4885GFER 3230/4885PDE4D 3074/4885 |
| US-10005782-B2 | Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators | BTK, LCK, SYK | GAA 2740/4885GFER 2859/4885PDE4D 997/4885 |
| US-20170073349-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | BTK, WEE1, LYN | GAA 2612/4885GFER 2034/4885PDE4D 3178/4885 |
| US-20160083392-A1 | Fused heterocyclic compounds as protein kinase inhibitors | BTK, WEE1, LYN | GAA 2612/4885GFER 2034/4885PDE4D 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.