Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20694706 | 0.84 | GRM6 (0.36) | GRM6CYP2C9CYP2C19NPSR1ALDH1A1 | |
| SCHEMBL5767590 | 0.79 | ALDH1A1 (0.46) | GRM6CYP2C9CYP2C19NPSR1ALDH1A1 | |
| SCHEMBL2324059 | 0.77 | PDE4D (0.71) | PDE4DALDH1A1LMNAGAAKDM4E | |
| SCHEMBL20075372 | 0.76 | PDE4D (0.39) | PDE4DGRM6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL1923447 | 0.74 | GAA (0.43) | PDE4DCYP2C19ALDH1A1LMNAGAA | |
| SCHEMBL15660193 | 0.74 | PDE4D (0.41) | PDE4DALDH1A1LMNAGAAKDM4E | |
| SCHEMBL13432017 | 0.71 | PDE4D (0.36) | PDE4D | |
| SCHEMBL2364836 | 0.71 | PDE4D (0.49) | PDE4DALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL4440046 | 0.70 | MAPK1 (0.50) | ALDH1A1LMNAKDM4EMAPTHPGD | |
| SCHEMBL29019219 | 0.69 | KDM4E (0.38) | GRM6CYP2C9CYP2C19NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008117051-A1 | S-6-METH0XY-2- (2- (3- (PYRIMID-2-YL) IS0XAZ0L-5-YL) PYRROLIDIN-1-YL) -4- (5-METHYL-IH-PYRAZOL-S-YLAMINO) PYRIMIDINE AND POLYMORPHIC FORMS THEREOF AS MODULATORS OF THE INSULIN-LIKE GROWTH | ASTRAZENECA AB (SE) | 2008-10-02 | — | — | WO | disclosed |