Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 2/20 | 0.42 |
| ▸ | TYMS | P04818 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14281548 | 0.77 | PARP1 (0.46) | ALDH1A1KDM4ELMNAGLAHSD17B10 | |
| SCHEMBL22118823 | 0.73 | KDM4E (0.42) | ALDH1A1KDM4ELMNAPMP22HSD17B10 | |
| SCHEMBL7379913 | 0.73 | TNKS2 (0.50) | TP53ALDH1A1KDM4EGLAMAPT | |
| SCHEMBL5799688 | 0.70 | TNKS (0.58) | ALOX15ALDH1A1HSD17B10MAPTMEN1 | |
| SCHEMBL19236510 | 0.69 | CYP1A2 (0.49) | MITFTP53THRBALOX15HBB | |
| SCHEMBL7420122 | 0.68 | CACNA1H (0.37) | ALDH1A1KDM4ELMNAPMP22HSD17B10 | |
| SCHEMBL4570270 | 0.67 | QTRT1 (0.56) | QTRT1ALDH1A1KDM4ELMNAGLA | |
| SCHEMBL826249 | 0.67 | TYMS (0.49) | QTRT1TYMS | |
| SCHEMBL14144916 | 0.67 | TYMS (0.49) | QTRT1TYMS | |
| SCHEMBL7422513 | 0.66 | ADORA3 (0.33) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136395-A1 | BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF | BIOCRYST PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |