Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17002553 | 0.81 | CYP1A2 (0.43) | POLBPKMGAAKMT2ARAB9A | |
| SCHEMBL1923869 | 0.80 | NPC1 (0.49) | GRIN1GRIN2BPOLBPKMMEN1 | |
| SCHEMBL22191835 | 0.79 | NPC1 (0.53) | POLBMEN1GAAKMT2AMAPT | |
| SCHEMBL17000121 | 0.77 | RIPK1 (0.49) | RIPK1GRIN1GRIN2BPOLBPKM | |
| SCHEMBL1923873 | 0.76 | HTT (0.42) | GRIN1GRIN2BMEN1KMT2AGSK3B | |
| SCHEMBL1925524 | 0.76 | RIPK1 (0.48) | RIPK1MEN1KMT2AGSK3BMAPT | |
| SCHEMBL29822933 | 0.73 | RIPK1 (0.71) | RIPK1GRIN1GRIN2BPOLBPKM | |
| SCHEMBL28642046 | 0.73 | RIPK1 (0.71) | RIPK1GRIN1GRIN2BPOLBPKM | |
| SCHEMBL31275117 | 0.73 | RAB9A (0.38) | PKMMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL18371614 | 0.72 | KLKB1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
| EP-1809628-B1 | PHENYLUREA DERIVATIVES USED AS INHIBITORS OF TYROSINKINASE FOR TREATING TUMORS | MERCK PATENT GMBH (DE) | 2011-06-08 | — | — | EP | disclosed |
| US-7696224-B2 | Phenylurea derivatives as inhibitors of tyrosine kinases for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2010-04-13 | — | — | US | disclosed |
| US-20080207682-A1 | Phenylurea Derivatives As Inhibitors Of Tyrosine Kinases For The Treatment Of Tumour Diseases | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| EP-1809628-A1 | PHENYLUREA DERIVATIVES USED AS INHIBITORS OF TYROSINKINASE FOR TREATING TUMORS | Merck Patent GmbH (DE) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006042599-A1 | PHENYLUREA DERIVATIVES USED AS INHIBITORS OF TYROSINKINASE FOR TREATING TUMORS | MERCK PATENT GMBH (DE) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | DDR2, DDR1, DDRGK1 | RIPK1 1423/4885GRIN1 1727/4885GRIN2B 1165/4885 |
| US-20080207682-A1 | Phenylurea Derivatives As Inhibitors Of Tyrosine Kinases For The Treatment Of Tumour Diseases | TIE1, RET, FLT1 | RIPK1 781/4885GRIN1 4587/4885GRIN2B 3345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.