Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417772 | 1.00 | ALDH1A1 (0.54) | ALDH1A1XIAPBIRC2HPGDALOX15 | |
| SCHEMBL4420179 | 1.00 | ALDH1A1 (0.54) | ALDH1A1XIAPBIRC2HPGDALOX15 | |
| SCHEMBL27634785 | 0.86 | ALDH1A1 (0.51) | ALDH1A1HPGDALOX15MGLLHSD17B10 | |
| SCHEMBL28510427 | 0.86 | ALDH1A1 (0.51) | ALDH1A1HPGDALOX15MGLLHSD17B10 | |
| SCHEMBL7658796 | 0.85 | HTT (0.50) | ALDH1A1HPGDTSHRSMN1; SMN2RAB9A | |
| SCHEMBL7655528 | 0.85 | HTT (0.50) | ALDH1A1HPGDTSHRSMN1; SMN2RAB9A | |
| SCHEMBL7657843 | 0.85 | HTT (0.50) | ALDH1A1HPGDTSHRSMN1; SMN2RAB9A | |
| SCHEMBL1922775 | 0.84 | USP2 (0.58) | ALDH1A1HPGDHSD17B10MAPTHDAC1 | |
| SCHEMBL22802008 | 0.84 | NPC1 (0.47) | ALDH1A1HSD17B10MAPTHDAC1ADRB1 | |
| SCHEMBL3770299 | 0.84 | NPC1 (0.47) | ALDH1A1HSD17B10MAPTHDAC1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102971291-A | Novel amide derivative and use thereof as medicine | MITSUBISHI TANABE PHARMA CORP | 2013-03-13 | — | — | CN | disclosed |
| CN-102123989-A | Pyrazole compounds 436 | ASTRAZENECA AB | 2011-07-13 | — | — | CN | disclosed |
| EP-2328872-A1 | PYRAZOLE COMPOUNDS 436 | AstraZeneca AB (SE) | 2011-06-08 | — | — | EP | disclosed |
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| WO-2009153592-A1 | PYRAZOLE COMPOUNDS 436 | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | CYP3A43, CYP3A7, CYP3A4 | ALDH1A1 283/4885XIAP 2432/4885BIRC2 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.