Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | PGR | P06401 | 3/20 | 0.74 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | TNF | P01375 | 1/20 | 0.73 |
| ▸ | IL6 | P05231 | 1/20 | 0.73 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.73 |
| ▸ | AR | P10275 | 1/20 | 0.73 |
| ▸ | GLUL | P15104 | 1/20 | 0.73 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172933 | 1.00 | HSD17B10 (0.74) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL21242937 | 1.00 | HSD17B10 (0.74) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL10414421 | 0.90 | LMNA (0.69) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL10602893 | 0.90 | LMNA (0.69) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL11737941 | 0.89 | HSD17B10 (0.61) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL22457118 | 0.89 | HSD17B10 (0.85) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL24325646 | 0.88 | LMNA (0.68) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL10865415 | 0.88 | LMNA (0.74) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL13558385 | 0.88 | LMNA (0.74) | HSD17B10HIF1ALMNAPGRNR3C1 | |
| SCHEMBL10380227 | 0.88 | LMNA (0.74) | HSD17B10HIF1ALMNAPGRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2752422-B1 | Stereoselective synthesis of phosphorus containing actives | GILEAD PHARMASSET LLC (US) | 2017-08-16 | — | — | EP | disclosed |