Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.66 |
| ▸ | SMO | Q99835 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161275 | 0.86 | HSD11B1 (0.58) | HSD11B1SMONOTUMKMT2A | |
| SCHEMBL5421718 | 0.80 | HSD11B1 (0.78) | HSD11B1SMOSMN1; SMN2POLBNOTUM | |
| SCHEMBL30756735 | 0.79 | HSD11B1 (1.00) | HSD11B1SMOSMN1; SMN2POLBNOTUM | |
| SCHEMBL26657989 | 0.79 | HSD11B1 (1.00) | HSD11B1SMOSMN1; SMN2POLBNOTUM | |
| SCHEMBL1854997 | 0.78 | HSD11B1 (0.79) | HSD11B1SMOSMN1; SMN2POLBNOTUM | |
| SCHEMBL28780902 | 0.78 | HSD11B1 (1.00) | HSD11B1SMO | |
| SCHEMBL1860172 | 0.78 | HSD11B1 (0.62) | HSD11B1SMOSMN1; SMN2POLBTSHR | |
| SCHEMBL3455811 | 0.77 | CHRM2 (0.47) | HSD11B1POLBTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL1857334 | 0.77 | HSD11B1 (0.78) | HSD11B1SMOSMN1; SMN2POLBNOTUM | |
| SCHEMBL1857637 | 0.77 | HSD11B1 (1.00) | HSD11B1SMOSMN1; SMN2POLBNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10039772-B2 | Methods and compositions for treating alcohol use disorders | SANNA PIETRO PAOLO (US) | 2018-08-07 | — | — | US | disclosed |
| US-10039772-B2 | Methods and compositions for treating alcohol use disorders | SANNA PIETRO PAOLO (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170232007-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | SANNA PIETRO PAOLO (US) | 2017-08-17 | — | — | US | disclosed |
| US-20170232007-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | SANNA PIETRO PAOLO (US) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10039772-B2 | Methods and compositions for treating alcohol use disorders | HSD3B1, HSD11B1, HSD3B2 | HSD11B1 2/4885SMO 4339/4885SMN1; SMN2 4743/4885 |
| US-20170232007-A1 | METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS | HSD3B1, HSD11B1, HSD3B2 | HSD11B1 2/4885SMO 4339/4885SMN1; SMN2 4743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.