Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLL | Q9UGP5 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11358726 | 0.77 | HTR2A (0.54) | GAACYP3A4CYP2C19HTR2AHTR2C | |
| SCHEMBL11352016 | 0.77 | KDM4E (0.47) | POLLKDM4EGAACYP3A4CYP2D6 | |
| SCHEMBL11363652 | 0.76 | CYP1A2 (0.48) | POLLKDM4EGAACYP3A4CYP2D6 | |
| SCHEMBL11362493 | 0.76 | POLL (0.42) | POLLKDM4EGAACYP3A4CYP2D6 | |
| SCHEMBL31452285 | 0.75 | POLL (0.44) | POLLKDM4EGAACYP3A4CYP2D6 | |
| SCHEMBL9966814 | 0.74 | PBRM1 (0.48) | GAACYP3A4CYP2C19HTR2AHTR2C | |
| SCHEMBL9140156 | 0.71 | POLL (0.53) | POLLKDM4EGAACYP3A4CYP2D6 | |
| SCHEMBL24743549 | 0.69 | PBRM1 (0.67) | KDM4EGAAKMT2AHTTALDH1A1 | |
| Nodulisporone SCHEMBL29991198 | 0.68 | POLL (1.00) | POLLKDM4EGAACYP3A4CYP2D6 | |
| SCHEMBL11353414 | 0.68 | KDM4E (0.40) | KDM4ECYP2C9CYP2C19CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730912-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2017-08-15 | — | — | US | disclosed |