Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.70 |
| ▸ | MTOR | P42345 | 1/20 | 0.70 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29363239 | 0.82 | IRAK4 (1.00) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL3600534 | 0.82 | IRAK4 (1.00) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL3600804 | 0.80 | NPC1 (0.69) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL6530642 | 0.77 | KDM4E (1.00) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL16261073 | 0.77 | MTOR (0.74) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL6529303 | 0.76 | KDM4E (0.69) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL13500540 | 0.75 | OPRK1 (0.86) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL175464 | 0.75 | IRAK4 (0.82) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL3600001 | 0.74 | MTOR (0.70) | IRAK4MTORIRAK1KDM4ENPSR1 | |
| SCHEMBL3606266 | 0.74 | CLK2 (0.72) | IRAK4MTORIRAK1KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999470-B1 | COMBINATION THERAPY FOR MDS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2017-08-16 | — | — | EP | disclosed |