Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.38 |
| ▸ | BCL2L11 | O43521 | 2/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | BID | P55957 | 1/20 | 0.37 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.37 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019540 | 0.79 | BCL2L1 (0.47) | KDM4EALDH1A1HPGDBCL2L11BCL2L1 | |
| SCHEMBL19250462 | 0.79 | PRMT5 (0.44) | TOP1KDM4EALDH1A1PRMT5PIP4K2C | |
| SCHEMBL13271032 | 0.79 | ALDH1A1 (0.56) | TOP1KDM4EALDH1A1HPGDPRMT5 | |
| SCHEMBL14666994 | 0.79 | PRMT5 (0.47) | TOP1KDM4EALDH1A1PRMT5PIP4K2C | |
| SCHEMBL23717084 | 0.72 | PDGFRB (0.46) | TOP1PRMT5PDGFRBPDGFRANPC1 | |
| SCHEMBL4569225 | 0.71 | ALDH1A1 (0.40) | TOP1KDM4EALDH1A1PRMT5PIP4K2C | |
| SCHEMBL14670848 | 0.70 | PRMT5 (0.38) | TOP1KDM4EALDH1A1PRMT5PDGFRB | |
| SCHEMBL7227501 | 0.70 | MEN1 (0.45) | KDM4EALDH1A1HPGDBCL2L11BCL2L1 | |
| SCHEMBL18368398 | 0.69 | BCL2L1 (0.56) | KDM4EALDH1A1HPGDBCL2L11BCL2L1 | |
| SCHEMBL7225702 | 0.69 | MAPT (0.46) | ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133664-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT， AMELIORATION OR PREVENTION OF INFLUENZA | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |