Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.39 |
| ▸ | LOX | P28300 | 2/20 | 0.39 |
| ▸ | LOXL3 | P58215 | 2/20 | 0.39 |
| ▸ | LOXL1 | Q08397 | 2/20 | 0.39 |
| ▸ | LOXL4 | Q96JB6 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249487 | 0.90 | PTGDR2 (0.35) | PTGDR2 | |
| SCHEMBL29594898 | 0.87 | LOXL2 (0.51) | LOXL2LOXLOXL3LOXL1LOXL4 | |
| SCHEMBL20915620 | 0.87 | LOXL2 (0.51) | LOXL2LOXLOXL3LOXL1LOXL4 | |
| SCHEMBL19249482 | 0.87 | LOXL2 (0.51) | LOXL2LOXLOXL3LOXL1LOXL4 | |
| SCHEMBL19249683 | 0.86 | PTGDR2 (0.34) | PTGDR2 | |
| SCHEMBL19249485 | 0.81 | LOXL2 (0.51) | LOXL2LOXLOXL3LOXL1LOXL4 | |
| SCHEMBL29594701 | 0.81 | LOXL2 (0.46) | LOXL2LOXLOXL3LOXL1LOXL4 | |
| SCHEMBL19249639 | 0.81 | LOXL2 (0.46) | LOXL2LOXLOXL3LOXL1LOXL4 | |
| SCHEMBL29596000 | 0.81 | LOXL2 (0.51) | LOXL2LOXLOXL3LOXL1LOXL4 | |
| SCHEMBL19249475 | 0.80 | BRD4 (0.31) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136871-A9 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2018-02-15 | — | — | WO | disclosed |
| WO-2017136871-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2017-08-17 | — | — | WO | disclosed |