Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237784 | 0.81 | ALDH1A1 (0.52) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL1845031 | 0.78 | ALDH1A1 (0.53) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL28835773 | 0.76 | ALDH1A1 (0.47) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL17320587 | 0.76 | ALDH1A1 (0.47) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL4620314 | 0.75 | ALDH1A1 (0.50) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL4620318 | 0.75 | ALDH1A1 (0.50) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL23089952 | 0.74 | SLC1A3 (0.48) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL12611216 | 0.72 | SLC1A3 (0.61) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL11254941 | 0.72 | ALDH1A1 (0.47) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA | |
| SCHEMBL2266382 | 0.71 | ALDH1A1 (0.69) | ALDH1A1SLC1A3SLC1A2SLC1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878987-B2 | HSP70 modulators and methods for making and using the same | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | MEMORIAL SLOAN KETTERING CANCER CENTER | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233352-A1 | HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME | HSPA2, HSP90AA1, HSP90AB1 | ALDH1A1 458/4885SLC1A3 4312/4885SLC1A2 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.