Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29310682 | 0.87 | HSD11B1 (0.46) | HSD11B1KDM4ENPC1RAB9AGAA | |
| SCHEMBL7243686 | 0.81 | KCNH2 (0.45) | KCNH2CHRNA7CDK4CCND1 | |
| SCHEMBL20231005 | 0.81 | KCNH2 (0.45) | KCNH2CHRNA7CDK4CCND1 | |
| SCHEMBL20322515 | 0.81 | KCNH2 (0.45) | KCNH2CHRNA7CDK4CCND1 | |
| SCHEMBL24680837 | 0.79 | HSD11B1 (0.53) | HSD11B1KCNH2CHRNA7 | |
| SCHEMBL14208021 | 0.79 | DRD2 (0.45) | KCNH2CHRNA7CDK4CCND1 | |
| SCHEMBL24681527 | 0.79 | CDK4 (0.47) | KCNH2CHRNA7CDK4CCND1 | |
| SCHEMBL21641736 | 0.79 | KCNH2 (0.44) | KCNH2CHRNA7KDM4ECDK4CCND1 | |
| SCHEMBL24680826 | 0.79 | HSD11B1 (0.53) | HSD11B1KCNH2CHRNA7 | |
| SCHEMBL30206136 | 0.79 | KCNH2 (0.44) | KCNH2CHRNA7CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46511-E1 | Fused pyrimidine derivatives for inhibition of tyrosine kinase activity | HANMI SCIENCE CO., LTD. (KR) | 2017-08-15 | — | — | US | disclosed |