Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12458294 | 0.81 | GAA (0.39) | — | |
| SCHEMBL22752309 | 0.78 | ALDH1A1 (0.32) | — | |
| SCHEMBL22778719 | 0.77 | — | — | |
| SCHEMBL12777855 | 0.74 | GABBR2 (0.39) | SCN10ASCN1AKCNH2SCN5ASCN9A | |
| SCHEMBL22752379 | 0.74 | — | — | |
| SCHEMBL22752627 | 0.71 | S1PR4 (0.32) | — | |
| SCHEMBL19251317 | 0.70 | S1PR1 (0.33) | — | |
| SCHEMBL19251222 | 0.69 | — | — | |
| SCHEMBL19996792 | 0.69 | PDE2A (0.33) | — | |
| SCHEMBL19251313 | 0.67 | CNR2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |