Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Dodecanoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 7/20 | 0.65 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.65 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.65 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.65 |
| ▸ | PPARG | P37231 | 7/20 | 0.65 |
| ▸ | PPARD | Q03181 | 7/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.65 |
| ▸ | FABP4 | P15090 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TLR2 | O60603 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.65 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | ESR1 | P03372 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octanoic Acid SCHEMBL153529 | 1.00 | GPR84 (0.65) | GPR84PPARGPPARDPPARAHDAC11 | |
| Palmitic Acid SCHEMBL27628966 | 1.00 | GPR84 (0.65) | GPR84PPARGPPARDPPARAHDAC11 | |
| Decanoic Acid SCHEMBL29213878 | 1.00 | GPR84 (0.65) | GPR84PPARGPPARDPPARAHDAC11 | |
| Stearic Acid SCHEMBL27497997 | 1.00 | GPR84 (0.65) | GPR84PPARGPPARDPPARAHDAC11 | |
| Palmitic Acid SCHEMBL25433590 | 0.98 | GPR84 (0.63) | GPR84PPARGPPARDPPARAHDAC11 | |
| Octanoic Acid SCHEMBL29221971 | 0.98 | GPR84 (0.63) | GPR84PPARGPPARDPPARAHDAC11 | |
| Hexanoate SCHEMBL28294725 | 0.98 | AKR1B1 (0.64) | GPR84PPARGPPARDPPARAHDAC11 | |
| Valeric Acid SCHEMBL28053697 | 0.92 | AKR1B1 (0.54) | GPR84PPARGPPARDPPARAHDAC11 | |
| Azelaic Acid SCHEMBL8093799 | 0.92 | GPR84 (0.58) | GPR84PPARGPPARDPPARAHDAC11 | |
| Octanedioate SCHEMBL21380514 | 0.92 | GPR84 (0.58) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395369-A1 | TRANSDERMAL ABSORPTION ENHANCER AND TRANSDERMAL ABSORPTION ENHANCEMENT AID | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2018-10-31 | — | — | EP | disclosed |
| EP-3395368-A1 | TRANSDERMAL ABSORPTION ENHANCER AND TRANSDERMAL ABSORPTION ENHANCEMENT AID | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2018-10-31 | — | — | EP | disclosed |
| EP-3213769-A1 | TRANSDERMAL-ABSORPTION-PROMOTER AND TRANSDERMAL-ABSORPTION-PROMOTING SUPPLEMENT | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2017-09-06 | — | — | EP | disclosed |
| US-20170239173-A1 | TRANSDERMAL ABSORPTION ENHANCER AND TRANSDERMAL ABSORPTION ENHANCEMENT AID | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2017-08-24 | — | — | US | disclosed |