Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 6/20 | 0.50 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.50 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | PPARD | Q03181 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL21380513 | 1.00 | GPR84 (0.58) | GPR84FFAR1FFAR4TSHRLMNA | |
| Pimelic Acid SCHEMBL21380517 | 1.00 | GPR84 (0.58) | GPR84FFAR1FFAR4TSHRLMNA | |
| Octanedioate SCHEMBL21380514 | 1.00 | GPR84 (0.58) | GPR84FFAR1FFAR4TSHRLMNA | |
| Adipic Acid SCHEMBL21380515 | 0.98 | LMNA (0.55) | GPR84FFAR1FFAR4TSHRLMNA | |
| Adipic Acid SCHEMBL27908020 | 0.95 | CYP3A4 (0.59) | GPR84FFAR1FFAR4TSHRLMNA | |
| Glutarate SCHEMBL17982128 | 0.93 | LMNA (0.55) | GPR84FFAR1FFAR4TSHRLMNA | |
| Octanoic Acid SCHEMBL153529 | 0.92 | GPR84 (0.65) | GPR84FFAR1FFAR4TSHRLMNA | |
| Dodecanoate SCHEMBL19253063 | 0.92 | GPR84 (0.65) | GPR84FFAR1FFAR4TSHRLMNA | |
| Decanoic Acid SCHEMBL29213878 | 0.92 | GPR84 (0.65) | GPR84FFAR1FFAR4TSHRLMNA | |
| Palmitic Acid SCHEMBL27628966 | 0.92 | GPR84 (0.65) | GPR84FFAR1FFAR4TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116637037-A | Preparation method and application of siRNA supermolecule microcapsule with whitening effect | 丁妈给力(北京)生物科技有限公司 | 2023-08-25 | — | — | CN | claimed |
| CN-116637037-A | Preparation method and application of siRNA supermolecule microcapsule with whitening effect | 丁妈给力(北京)生物科技有限公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-116059129-A | Skin moisturizer and preparation method thereof | 广东丸美生物技术股份有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-114028262-A | Preparation method and application of azelaic acid ionic salt/eutectic cyclodextrin inclusion compound liposome | 深圳市萱嘉生物科技有限公司 | 2022-02-11 | — | — | CN | disclosed |
| US-20190292572-A1 | Novel protic or phosphate-based ionic liquids useful for lignocellulosic processing | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) | 2019-09-26 | — | — | US | disclosed |
| US-6120779-A | MOISTURIZING | SOMA TECHNOLOGIES (US) | 2000-09-19 | — | — | US | disclosed |