Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 5/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.46 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.46 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.46 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253227 | 0.80 | AKR1B10 (0.54) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL16010063 | 0.75 | CYP19A1 (0.59) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL16020107 | 0.74 | CYP19A1 (0.48) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL13688161 | 0.74 | AKR1B10 (0.53) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL19253253 | 0.73 | CYP19A1 (0.50) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL16769631 | 0.72 | SHBG (0.73) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL14438616 | 0.72 | SHBG (0.73) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL4995637 | 0.72 | SHBG (0.73) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL14438592 | 0.72 | SHBG (0.73) | SHBGCYP19A1GPBAR1NR3C1PGR | |
| SCHEMBL14046172 | 0.72 | SHBG (0.73) | SHBGCYP19A1GPBAR1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3260462-B1 | AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2019-04-17 | — | — | EP | disclosed |
| US-10017535-B2 | Amphiphilic compounds with neuroprotective properties | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-07-10 | — | — | US | disclosed |
| EP-3260462-A1 | AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES | Ustav Organicke Chemie A Biochemie Av Cr, V.v.i. (CZ) | 2017-12-27 | — | — | EP | disclosed |
| US-20170240588-A1 | AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2017-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170240588-A1 | AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES | GAP43, GRIN2A, GRIN3A | SHBG 3674/4885CYP19A1 2192/4885GPBAR1 287/4885 |
| US-10017535-B2 | Amphiphilic compounds with neuroprotective properties | GAP43, GRIN2A, GRIN3A | SHBG 3674/4885CYP19A1 2192/4885GPBAR1 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.