Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.69 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.69 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.62 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.46 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70173 | 0.87 | CYP4F2 (0.83) | CYP4F2CYP4A11LOXL2SLC7A5FOLH1 | |
| SCHEMBL9368512 | 0.86 | MRGPRX4 (0.65) | CYP4F2CYP4A11LOXL2MRGPRX4ALDH1A1 | |
| SCHEMBL27595412 | 0.85 | CYP4F2 (0.66) | CYP4F2CYP4A11LOXL2SLC7A5FOLH1 | |
| SCHEMBL1790854 | 0.84 | SLC7A5 (0.68) | CYP4F2CYP4A11LOXL2SLC7A5FOLH1 | |
| SCHEMBL27955126 | 0.82 | SLC7A5 (0.75) | CYP4F2CYP4A11LOXL2SLC7A5FOLH1 | |
| SCHEMBL27955127 | 0.82 | SLC7A5 (0.75) | CYP4F2CYP4A11LOXL2SLC7A5FOLH1 | |
| SCHEMBL13126937 | 0.82 | MAP1LC3B (0.47) | CYP4F2CYP4A11MRGPRX4HPGDMAP1LC3B | |
| SCHEMBL46931 | 0.82 | CYP4A11 (1.00) | CYP4F2CYP4A11LOXL2SLC7A5FOLH1 | |
| SCHEMBL10609527 | 0.82 | CYP4F2 (0.76) | CYP4F2CYP4A11LOXL2SLC7A5FOLH1 | |
| SCHEMBL848969 | 0.82 | FOLH1 (0.56) | FOLH1MRGPRX4KDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-B1 | ALPHA-HELICAL MIMETICS | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-7956216-B2 | Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2011-06-07 | — | — | US | disclosed |
| US-20080153802-A1 | Alpha-helical mimetics | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-06-26 | — | — | US | disclosed |
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153802-A1 | Alpha-helical mimetics | BID, BAX, BAD | CYP4F2 4708/4885CYP4A11 4842/4885LOXL2 3404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.