Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 6/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19254475 | 0.84 | EGFR (0.49) | EGFRALK | |
| SCHEMBL29595342 | 0.81 | AURKA (0.44) | EGFRALKCDK9AURKAAURKB | |
| SCHEMBL28729729 | 0.81 | AURKA (0.44) | EGFRALKCDK9AURKAAURKB | |
| SCHEMBL28729877 | 0.80 | EGFR (0.43) | EGFRALKCDK9CCNT1AURKA | |
| SCHEMBL30948608 | 0.79 | EGFR (0.50) | EGFRALKCDK9AURKAAURKB | |
| SCHEMBL28663733 | 0.79 | MAP4K1 (0.58) | EGFRALKAURKAIGF1RMAP4K1 | |
| SCHEMBL30108148 | 0.78 | ALK (0.42) | EGFRALKCDK9CCNT1AURKA | |
| SCHEMBL30948589 | 0.78 | CCNT1 (0.42) | EGFRALKCDK9CCNT1AURKB | |
| SCHEMBL23761671 | 0.78 | EGFR (0.54) | EGFRALKCDK9CCNT1AURKA | |
| SCHEMBL31630575 | 0.78 | EGFR (0.54) | EGFRALKCDK9CCNT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205650-A1 | EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2017-08-16 | — | — | EP | disclosed |