Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12201883 | 0.83 | HDAC8 (0.77) | HDAC8HDAC6KDM4EEGLN2HDAC3 | |
| SCHEMBL3433869 | 0.81 | KIF11 (0.49) | ALDH1A1POLBBRAFSMN1; SMN2 | |
| SCHEMBL120251 | 0.81 | NPC1 (0.64) | POLBKMT2A | |
| SCHEMBL12229090 | 0.81 | SMYD3 (0.55) | KDM4EALDH1A1POLBTAS1R3TAS1R1 | |
| SCHEMBL1787753 | 0.81 | LOXL2 (0.51) | KDM4EALDH1A1POLBBRAF | |
| SCHEMBL1696789 | 0.80 | PARP1 (0.50) | ALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL27886595 | 0.77 | NPC1 (0.49) | ALDH1A1POLBTAS1R3TAS1R1BRAF | |
| SCHEMBL13227566 | 0.76 | AKT1 (0.46) | KDM4EALDH1A1POLBTAS1R3TAS1R1 | |
| SCHEMBL1788857 | 0.76 | CYP4F2 (0.51) | KDM4EALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL13969558 | 0.76 | HPGD (0.59) | HDAC8ALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732078-B2 | Therapeutic use of imidazopyridine derivatives | SANOFI (FR) | 2017-08-15 | — | — | US | disclosed |