Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23728980 | 0.80 | EGFR (0.48) | ALKEGFR | |
| SCHEMBL28729877 | 0.77 | EGFR (0.43) | ALKEGFRMAPTMEN1KMT2A | |
| SCHEMBL19254474 | 0.76 | EGFR (0.42) | ALKEGFRPLK1SMN1; SMN2LMNA | |
| SCHEMBL23461800 | 0.75 | EGFR (0.39) | ALKEGFRMAPTMEN1KMT2A | |
| SCHEMBL31029505 | 0.75 | EGFR (0.39) | ALKEGFRMAPTMEN1KMT2A | |
| SCHEMBL30948608 | 0.75 | EGFR (0.50) | ALKEGFRMEN1KMT2AL3MBTL1 | |
| SCHEMBL17683364 | 0.75 | KDR (0.54) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30459722 | 0.75 | KDR (0.54) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL28614583 | 0.75 | EGFR (0.43) | EGFR | |
| SCHEMBL28663733 | 0.75 | MAP4K1 (0.58) | ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205650-A1 | EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2017-08-16 | — | — | EP | disclosed |