Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25551342 | 0.81 | RIPK1 (0.43) | RIPK1CRBNDDB1TGM2 | |
| SCHEMBL28714243 | 0.78 | RIPK1 (0.52) | RIPK1CRBN | |
| SCHEMBL22737131 | 0.78 | RIPK1 (0.52) | RIPK1CRBN | |
| SCHEMBL29467170 | 0.78 | RIPK1 (0.41) | RIPK1CRBNDDB1TGM2 | |
| SCHEMBL15964533 | 0.78 | RIPK1 (0.41) | RIPK1CRBNDDB1TGM2 | |
| SCHEMBL15964668 | 0.78 | RIPK1 (0.41) | RIPK1CRBNDDB1TGM2 | |
| SCHEMBL15964688 | 0.78 | RIPK1 (0.41) | RIPK1CRBNDDB1TGM2 | |
| SCHEMBL29467194 | 0.78 | RIPK1 (0.41) | RIPK1CRBNDDB1TGM2 | |
| SCHEMBL30039522 | 0.78 | RIPK1 (0.41) | RIPK1CRBNDDB1TGM2 | |
| SCHEMBL19659466 | 0.73 | RIPK1 (0.34) | RIPK1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |