Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28714243 | 1.00 | RIPK1 (0.52) | RIPK1GAASCN9ACRBN | |
| SCHEMBL22737129 | 0.88 | RIPK1 (0.41) | RIPK1GAASCN9A | |
| SCHEMBL17040899 | 0.81 | BDKRB1 (0.44) | GAASCN9A | |
| SCHEMBL25764042 | 0.81 | GAA (0.41) | RIPK1GAACRBN | |
| SCHEMBL29467186 | 0.79 | GAA (0.50) | RIPK1GAA | |
| SCHEMBL17321204 | 0.79 | GAA (0.50) | RIPK1GAA | |
| SCHEMBL30035060 | 0.79 | GAA (0.50) | RIPK1GAA | |
| SCHEMBL28716146 | 0.79 | GAA (0.50) | RIPK1GAA | |
| SCHEMBL19255068 | 0.78 | RIPK1 (0.50) | RIPK1CRBN | |
| SCHEMBL22969007 | 0.77 | DDB1 (0.41) | RIPK1SCN9ACRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239074-A1 | BICYCLIC COMPOUND AS RIP-1 KINASE INHIBITOR AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-12-03 | — | — | WO | disclosed |