Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 7/20 | 0.47 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | NT5M | Q9NPB1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22172535 | 0.92 | TK1 (0.48) | TK1RNASE1POLBDHFRNT5M | |
| SCHEMBL24059078 | 0.84 | TK1 (0.45) | TK1RNASE1POLB | |
| SCHEMBL22021036 | 0.84 | TK1 (0.62) | TK1POLB | |
| SCHEMBL22021811 | 0.84 | TK1 (0.62) | TK1POLB | |
| SCHEMBL22111998 | 0.84 | TK1 (0.62) | TK1POLB | |
| SCHEMBL24233023 | 0.84 | TK1 (0.62) | TK1POLB | |
| SCHEMBL18715468 | 0.83 | TK1 (0.49) | TK1RNASE1POLBDHFRNT5M | |
| SCHEMBL20814256 | 0.82 | TK1 (0.48) | TK1RNASE1POLBDHFRNT5M | |
| SCHEMBL18708266 | 0.79 | TK1 (0.47) | TK1RNASE1POLBDHFRNT5M | |
| SCHEMBL21592101 | 0.79 | POLB (0.50) | TK1RNASE1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017059223-A9 | COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF LPA | Arrowhead Pharmaceuticals, Inc. (US) | 2017-08-17 | — | — | WO | disclosed |