Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 14/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.38 |
| ▸ | LOXL1 | Q08397 | 1/20 | 0.38 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19254634 | 0.89 | LOXL2 (0.51) | LOXL2DAOAOC3LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL28565642 | 0.88 | LOXL2 (0.52) | RAD52LOXL2DAOAOC3LOX | |
| SCHEMBL20699533 | 0.83 | RAD52 (0.43) | RAD52F2RL3LOXL2MAPTMEN1 | |
| SCHEMBL20699598 | 0.74 | LOXL2 (0.62) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL20699601 | 0.74 | LOXL2 (0.62) | LOXL2DAOAOC3LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL19211823 | 0.71 | LOXL2 (0.73) | LOXL2DAOAOC3LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL20699614 | 0.70 | LOXL2 (0.61) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255048 | 0.70 | LOXL2 (0.42) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255571 | 0.70 | LOXL2 (0.37) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255694 | 0.70 | LOXL2 (0.71) | LOXL2DAOAOC3LOXLOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136870-A9 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2018-02-15 | — | — | WO | disclosed |
| WO-2017136870-A1 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2017-08-17 | — | — | WO | disclosed |