Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 12/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.37 |
| ▸ | LOXL1 | Q08397 | 1/20 | 0.37 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19254634 | 0.87 | LOXL2 (0.51) | LOXL2DAOAOC3LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL28565642 | 0.86 | LOXL2 (0.52) | RAD52LOXL2DAOAOC3LOX | |
| SCHEMBL19255581 | 0.83 | RAD52 (0.42) | RAD52LOXL2MEN1KMT2ALMNA | |
| SCHEMBL20699597 | 0.73 | LOXL2 (0.54) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL20699562 | 0.73 | LOXL2 (0.55) | LOXL2DAOAOC3LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL19211823 | 0.70 | LOXL2 (0.73) | LOXL2DAOAOC3LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL20699614 | 0.69 | LOXL2 (0.61) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL19255694 | 0.67 | LOXL2 (0.71) | LOXL2DAOAOC3LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL20699705 | 0.67 | LOXL2 (0.72) | LOXL2DAOAOC3LOXLOXL3 | |
| SCHEMBL20699520 | 0.67 | LOXL2 (0.71) | LOXL2DAOAOC3LOXLOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200317666-A1 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2020-10-08 | — | — | US | disclosed |
| US-10717733-B2 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | PHARMAXIS LTD. (AU) | 2020-07-21 | — | — | US | disclosed |
| US-20190040007-A1 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2019-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10717733-B2 | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | IDO1, IDO2, INMT | RAD52 2266/4885PLA2G2A 2178/4885LOXL2 24/4885 |
| US-20190040007-A1 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | IDO1, IDO2, INMT | RAD52 2266/4885PLA2G2A 2178/4885LOXL2 24/4885 |
| US-20200317666-A1 | HALOALLYLAMINE INDOLE AND AZAINDOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | IDO1, IDO2, INMT | RAD52 2266/4885PLA2G2A 2178/4885LOXL2 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.