Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 16/20 | 0.67 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19228518 | 0.88 | RIPK1 (0.69) | RIPK1USP2MEN1KMT2AALDH1A1 | |
| SCHEMBL19255772 | 0.87 | RIPK1 (0.68) | RIPK1USP2MEN1KMT2AALDH1A1 | |
| SCHEMBL19228578 | 0.80 | RIPK1 (1.00) | RIPK1USP2MEN1KMT2A | |
| SCHEMBL29415758 | 0.80 | RIPK1 (1.00) | RIPK1USP2MEN1KMT2A | |
| SCHEMBL29415756 | 0.80 | RIPK1 (1.00) | RIPK1USP2MEN1KMT2A | |
| SCHEMBL19228324 | 0.80 | RIPK1 (1.00) | RIPK1USP2MEN1KMT2A | |
| SCHEMBL19228249 | 0.79 | RIPK1 (0.75) | RIPK1USP2MEN1KMT2AALDH1A1 | |
| SCHEMBL19255754 | 0.79 | RIPK1 (0.66) | RIPK1LMNAMAPT | |
| SCHEMBL19228253 | 0.78 | RIPK1 (0.73) | RIPK1USP2MEN1KMT2AALDH1A1 | |
| SCHEMBL19228251 | 0.78 | RIPK1 (0.73) | RIPK1USP2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |