Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 17/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19228300 | 0.88 | RIPK1 (0.69) | RIPK1LMNAPOLBTHRBMAPT | |
| SCHEMBL20904009 | 0.81 | RIPK1 (0.66) | RIPK1LMNAPOLBTHRB | |
| SCHEMBL29415770 | 0.80 | RIPK1 (1.00) | RIPK1LMNAPOLBTHRB | |
| SCHEMBL19805406 | 0.80 | RIPK1 (1.00) | RIPK1LMNAPOLBTHRB | |
| SCHEMBL29415638 | 0.80 | RIPK1 (1.00) | RIPK1LMNAPOLBTHRB | |
| SCHEMBL19228316 | 0.80 | RIPK1 (1.00) | RIPK1LMNAPOLBTHRB | |
| SCHEMBL19228427 | 0.79 | RIPK1 (0.76) | RIPK1LMNAPOLBTHRBMAPT | |
| SCHEMBL19255630 | 0.79 | RIPK1 (0.67) | RIPK1LMNAMAPT | |
| SCHEMBL19228429 | 0.77 | RIPK1 (0.73) | RIPK1LMNAPOLBTHRBMAPT | |
| SCHEMBL19805397 | 0.77 | RIPK1 (0.73) | RIPK1LMNAPOLBTHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |