SCHEMBL19255949

SCHEMBL19255949

Cc1cc(F)c2[nH]nc(-c3nc(N)c(F)c(C4CC4)n3)c2c1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SGK1 O00141 1/20 0.31
ILK Q13418 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19255178 0.76 MAPK1 (0.31) ILK
SCHEMBL21345178 0.74 PIK3CG (0.33)
SCHEMBL19250417 0.71 KDM4E (0.34)
SCHEMBL19255585 0.68 REN (0.34)
SCHEMBL22893985 0.66
SCHEMBL19250615 0.65 HCAR2 (0.34)
SCHEMBL13122336 0.63 ADORA2A (0.49)
SCHEMBL30900914 0.63 PDK2 (0.38) ILK
SCHEMBL19250876 0.63 PDK2 (0.35)
SCHEMBL19255693 0.63 EGFR (0.31) SGK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017133670-A1 PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA SAVIRA PHARMACEUTICALS GMBH (AT) 2017-08-10 WO disclosed