Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572134 | 0.87 | CCNC (0.48) | CCNCCDK8HTTSMN1; SMN2LMNA | |
| SCHEMBL1572666 | 0.83 | KMT2A (0.39) | CCNCCDK8HTTSMN1; SMN2LMNA | |
| SCHEMBL16416790 | 0.72 | CCNC (0.52) | CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL6605048 | 0.68 | HTT (0.55) | HTTSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL30888473 | 0.66 | CCNC (0.41) | CCNCCDK8SMN1; SMN2 | |
| SCHEMBL3202792 | 0.66 | ALDH1A1 (0.44) | CCNCCDK8HTTSMN1; SMN2LMNA | |
| SCHEMBL27351271 | 0.66 | TUBB4A (0.43) | CCNCCDK8LMNAALDH1A1 | |
| SCHEMBL5062781 | 0.65 | — | — | |
| SCHEMBL29069430 | 0.65 | MAP4K4 (0.41) | CCNCCDK8SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3917369 | 0.64 | HTR2A (0.45) | HTTSMN1; SMN2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110129455-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129455-A1 | INHIBITORS OF AKT ACTIVITY | AKT2, AKT1, PI4KB | CCNC 235/4885CDK8 102/4885HTT 1472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.