Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19257395 | 0.90 | CYP17A1 (0.37) | CYP17A1BRAFADRA2AALDH1A1HSD17B10 | |
| SCHEMBL18595671 | 0.89 | CYP17A1 (0.41) | CYP17A1PIK3C3PIK3CABRAFADRA2A | |
| SCHEMBL18024067 | 0.82 | CYP17A1 (0.46) | CYP17A1PIK3C3PIK3CABRAFADRA2A | |
| SCHEMBL17996190 | 0.77 | BRD4 (0.40) | PIK3C3PIK3CAALDH1A1HSD17B10LMNA | |
| SCHEMBL19257549 | 0.77 | SLC22A12 (0.42) | CYP17A1CTSSCTSKPPARGPPARA | |
| SCHEMBL18595668 | 0.77 | CYP17A1 (0.39) | CYP17A1BRAFADRA2AALDH1A1HSD17B10 | |
| SCHEMBL18024066 | 0.72 | CYP17A1 (0.45) | CYP17A1BRAFADRA2AALDH1A1CTSS | |
| SCHEMBL29338792 | 0.68 | PIK3C3 (0.39) | CYP17A1PIK3C3PIK3CAALDH1A1HSD17B10 | |
| SCHEMBL24609148 | 0.68 | PIK3C3 (0.44) | PIK3C3PIK3CAALDH1A1LMNA | |
| SCHEMBL18595669 | 0.67 | BRD4 (0.44) | PIK3C3PIK3CAALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10022387-B2 | Aza-heteroaryl compounds as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170232016-A1 | AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170232016-A1 | AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS | PIK3R5, PIK3R1, PIK3R3 | CYP17A1 1111/4885PIK3C3 13/4885PIK3CA 8/4885 |
| US-10022387-B2 | Aza-heteroaryl compounds as PI3K-gamma inhibitors | PIK3R5, PIK3R1, PIK3R3 | CYP17A1 1111/4885PIK3C3 13/4885PIK3CA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.