Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17996190 | 0.83 | BRD4 (0.40) | PIK3C3PIK3CABRD4ALDH1A1HSD17B10 | |
| SCHEMBL18595671 | 0.76 | CYP17A1 (0.41) | PIK3C3PIK3CAALDH1A1HSD17B10KDM4E | |
| SCHEMBL24609148 | 0.74 | PIK3C3 (0.44) | PIK3C3PIK3CAALDH1A1KDM4ETRPV1 | |
| SCHEMBL19728988 | 0.72 | PIK3CD (0.40) | PIK3C3PIK3CAALDH1A1PTGES2 | |
| SCHEMBL17996189 | 0.69 | PSIP1 (0.42) | BRD4ALDH1A1HSD17B10HPGDTRPV1 | |
| SCHEMBL19257097 | 0.68 | CYP17A1 (0.39) | PIK3C3PIK3CAALDH1A1HSD17B10CYP17A1 | |
| SCHEMBL17946248 | 0.66 | HPGD (0.42) | PIK3CAALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL18595669 | 0.65 | BRD4 (0.44) | PIK3C3PIK3CABRD4ALDH1A1HSD17B10 | |
| SCHEMBL20578655 | 0.64 | PIK3C3 (0.38) | PIK3C3KDM4EMAPTTRPV1 | |
| SCHEMBL18595668 | 0.63 | CYP17A1 (0.39) | ALDH1A1HSD17B10PTGES2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239764-A1 | SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239764-A1 | SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS | EGFR, ERBB2, ERBB3 | PIK3C3 32/4885PIK3CA 8/4885BRD4 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.