⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL97778 | 0.81 | ALDH1A1 (0.50) | — | |
| SCHEMBL6548307 | 0.75 | ALDH1A1 (0.44) | — | |
| SCHEMBL925796 | 0.75 | — | — | |
| SCHEMBL11170147 | 0.75 | ALDH1A1 (0.44) | — | |
| SCHEMBL18665263 | 0.74 | — | — | |
| SCHEMBL14645381 | 0.71 | — | — | |
| SCHEMBL31506420 | 0.70 | ALDH1A1 (0.33) | — | |
| SCHEMBL14775080 | 0.69 | TSHR (0.39) | — | |
| SCHEMBL361130 | 0.67 | — | — | |
| SCHEMBL2991686 | 0.65 | ALDH1A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889815-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2021-01-12 | — | — | US | disclosed |
| US-10000754-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170298355-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) | BANK OF AMERICA, N.A. | 2017-10-19 | — | — | US | disclosed |
| EP-3222294-A1 | CONJUGATES AND COMPOSITIONS FOR CELLULAR DELIVERY | Sirna Therapeutics, Inc. (US) | 2017-09-27 | — | — | EP | disclosed |
| US-9771588-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-9732344-B2 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2017-08-15 | — | — | US | disclosed |