Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 4/20 | 0.42 |
| ▸ | NMT2 | O60551 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
| ▸ | FURIN | P09958 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19257729 | 0.91 | NMT1 (0.43) | NMT1NMT2PTGS1PTGS2SLC6A5 | |
| SCHEMBL22267881 | 0.89 | NMT1 (0.40) | NMT1NMT2CTSLPTGS1PTGS2 | |
| SCHEMBL17722905 | 0.89 | PTGS1 (0.49) | PTGS1PTGS2HDAC1HSP90AA1TLR9 | |
| SCHEMBL23256221 | 0.88 | NPY5R (0.38) | NMT1NMT2CTSLPTGS1PTGS2 | |
| SCHEMBL20263646 | 0.88 | SLC6A5 (0.44) | NMT1NMT2CTSLPTGS1PTGS2 | |
| SCHEMBL13078356 | 0.88 | NPY5R (0.38) | NMT1NMT2CTSLPTGS1PTGS2 | |
| SCHEMBL19257624 | 0.88 | NPY5R (0.38) | NMT1NMT2CTSLPTGS1PTGS2 | |
| SCHEMBL23222064 | 0.88 | PTGS1 (0.36) | NMT1NMT2CTSLPTGS1PTGS2 | |
| SCHEMBL19257728 | 0.85 | NMT1 (0.39) | NMT1NMT2CTSLSLC6A5HRH1 | |
| SCHEMBL26279661 | 0.84 | PTGS1 (0.44) | NMT1NMT2PTGS1PTGS2SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |