Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 9/20 | 0.39 |
| ▸ | NMT2 | O60551 | 8/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | FURIN | P09958 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22841014 | 0.90 | CASP1 (0.36) | HRH1 | |
| SCHEMBL19257730 | 0.85 | NMT1 (0.42) | NMT1NMT2CTSLHRH1SLC6A5 | |
| SCHEMBL22238251 | 0.84 | EPHX2 (0.35) | — | |
| SCHEMBL24860469 | 0.82 | C3AR1 (0.36) | NMT1NMT2FURIN | |
| SCHEMBL26083211 | 0.82 | CASP1 (0.35) | HRH1 | |
| SCHEMBL22267887 | 0.81 | CASP1 (0.33) | NMT1NMT2CTSLFURIN | |
| SCHEMBL21153657 | 0.80 | EPHX2 (0.42) | — | |
| SCHEMBL22388826 | 0.78 | NOD1 (0.39) | SLC6A5 | |
| SCHEMBL23583708 | 0.77 | MEN1 (0.45) | — | |
| SCHEMBL24128941 | 0.76 | FAP (0.38) | NMT1NMT2FURINROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |