Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.66 |
| ▸ | RAF1 | P04049 | 13/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | KIF5B | P33176 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19258524 | 0.89 | BRAF (0.64) | BRAFRAF1AURKAEGFRRET | |
| SCHEMBL19258532 | 0.85 | RAF1 (0.60) | BRAFRAF1AURKAEGFRRET | |
| SCHEMBL19258118 | 0.85 | BRAF (0.62) | BRAFRAF1EGFRRETKIF5B | |
| SCHEMBL13680227 | 0.84 | BRAF (0.64) | BRAFRAF1EGFRRETKIF5B | |
| SCHEMBL16692928 | 0.81 | BRAF (0.56) | BRAFRAF1EGFRRETKIF5B | |
| SCHEMBL19258211 | 0.81 | BRAF (0.61) | BRAFRAF1AURKAEGFRKDR | |
| SCHEMBL17920819 | 0.80 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL13680228 | 0.80 | BRAF (0.62) | BRAFRAF1EGFRRETKIF5B | |
| SCHEMBL16692920 | 0.79 | BRAF (0.71) | BRAFRAF1 | |
| SCHEMBL19258478 | 0.77 | BRAF (0.64) | BRAFRAF1EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |