Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.61 |
| ▸ | RAF1 | P04049 | 8/20 | 0.61 |
| ▸ | KDM1A | O60341 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 6/20 | 0.59 |
| ▸ | EGFR | P00533 | 5/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 4/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19258532 | 0.95 | RAF1 (0.60) | BRAFRAF1KDM1AKDREGFR | |
| SCHEMBL19258118 | 0.92 | BRAF (0.62) | BRAFRAF1KDM1AKDREGFR | |
| SCHEMBL19258478 | 0.89 | BRAF (0.64) | BRAFRAF1KDM1AKDREGFR | |
| SCHEMBL19258524 | 0.87 | BRAF (0.64) | BRAFRAF1KDM1AKDREGFR | |
| SCHEMBL19916608 | 0.85 | RAF1 (0.60) | BRAFRAF1KDM1AKDREGFR | |
| SCHEMBL1064552 | 0.81 | BRAF (0.71) | BRAFRAF1 | |
| SCHEMBL19258107 | 0.81 | KDR (0.73) | BRAFRAF1KDREGFRKIT | |
| SCHEMBL19258533 | 0.81 | BRAF (0.66) | BRAFRAF1KDREGFRKIT | |
| SCHEMBL16692912 | 0.81 | KDM1A (0.66) | BRAFRAF1KDM1AKDREGFR | |
| Hydrochloric Acid SCHEMBL30891785 | 0.80 | EGFR (0.84) | KDREGFRFLT4FGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |