Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.60 |
| ▸ | BRAF | P15056 | 7/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19258211 | 0.95 | BRAF (0.61) | RAF1BRAFKITAURKAKDM1A | |
| SCHEMBL19916608 | 0.90 | RAF1 (0.60) | RAF1BRAFKITKDM1AEGFR | |
| SCHEMBL19258118 | 0.87 | BRAF (0.62) | RAF1BRAFKDM1AEGFRKDR | |
| SCHEMBL19258533 | 0.85 | BRAF (0.66) | RAF1BRAFKITAURKAEGFR | |
| SCHEMBL19258478 | 0.84 | BRAF (0.64) | RAF1BRAFKDM1AEGFRKDR | |
| SCHEMBL13680228 | 0.82 | BRAF (0.62) | RAF1BRAFEGFRKDRRET | |
| SCHEMBL19258524 | 0.82 | BRAF (0.64) | RAF1BRAFAURKAKDM1AEGFR | |
| SCHEMBL16692921 | 0.82 | BRAF (0.54) | RAF1BRAFKDM1AEGFRKDR | |
| SCHEMBL19258530 | 0.82 | RAF1 (0.60) | RAF1BRAFEGFRKDRRET | |
| SCHEMBL7211076 | 0.81 | KDR (0.66) | RAF1BRAFKITAURKAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |