Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 1/20 | 0.63 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.63 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.63 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.61 |
| ▸ | CDK8 | P49336 | 1/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780615 | 0.90 | KCNJ6 (0.67) | KCNJ6KCNJ5KCNJ3MAPK13MAPK12 | |
| SCHEMBL5164195 | 0.86 | CDK8 (0.80) | CDK8MAPK13MAPK12MAPK11MAPK14 | |
| Hydrochloric Acid SCHEMBL29397175 | 0.85 | CDK8 (0.78) | CDK8MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1013684 | 0.82 | KCNJ6 (0.58) | KCNJ6KCNJ5KCNJ3MAPK13MAPK12 | |
| SCHEMBL27584609 | 0.78 | KLKB1 (0.61) | KCNJ6KCNJ5KCNJ3NR3C2PTGS1 | |
| SCHEMBL13975495 | 0.78 | NTRK1 (0.78) | KCNJ6KCNJ5KCNJ3GAAALDH1A1 | |
| SCHEMBL29397706 | 0.77 | KCNJ6 (0.70) | KCNJ6KCNJ5KCNJ3CDK8MAPK13 | |
| SCHEMBL8638165 | 0.77 | PTGS2 (0.60) | GAAPTGS1PDPK1GRM5 | |
| SCHEMBL6127413 | 0.76 | NR3C2 (1.00) | NR3C2PTGS1PDPK1 | |
| SCHEMBL1010908 | 0.76 | KCNJ6 (0.84) | KCNJ6KCNJ5KCNJ3MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |
| CN-102026985-A | Quinazoline derivatives as RAF kinase modulators and methods and uses thereof | AMBIT BIOSCIENCES CORPORATON | 2011-04-20 | — | — | CN | disclosed |
| CN-101553232-A | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-10-07 | — | — | CN | disclosed |