Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CTRC | Q99895 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207317 | 0.89 | NR3C2 (0.39) | NR3C2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL19207333 | 0.88 | NR3C2 (0.38) | NR3C2LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL19207334 | 0.88 | CNR1 (0.43) | NR3C2LMNARIPK1CTRC | |
| SCHEMBL19207322 | 0.88 | LMNA (0.39) | NR3C2LMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL19207341 | 0.88 | LMNA (0.47) | NR3C2LMNAKDM4EMEN1KMT2A | |
| SCHEMBL19207259 | 0.86 | RAB9A (0.45) | NR3C2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL19207256 | 0.86 | P2RY14 (0.42) | NR3C2LMNAKDM4EALDH1A1RIPK1 | |
| SCHEMBL19207303 | 0.85 | EGLN2 (0.41) | NR3C2LMNA | |
| SCHEMBL19207310 | 0.84 | NR3C2 (0.36) | NR3C2LMNAHDAC6RIPK1 | |
| SCHEMBL19207306 | 0.84 | NR3C2 (0.37) | NR3C2LMNAALDH1A1RIPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411365-B1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-11-20 | — | — | EP | disclosed |
| WO-2017133990-A1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-10 | — | — | WO | disclosed |