Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207339 | 0.88 | CTRC (0.39) | RIPK1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL19207304 | 0.87 | CNR1 (0.45) | RIPK1LMNACNR1 | |
| SCHEMBL19207284 | 0.87 | MAPT (0.40) | RIPK1LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL19207262 | 0.87 | LMNA (0.46) | RIPK1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL19207288 | 0.85 | GAA (0.37) | RIPK1LMNAHPGDCNR1CACNA1B | |
| SCHEMBL19207276 | 0.85 | P2RY14 (0.44) | RIPK1LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL19207324 | 0.85 | NPC1 (0.46) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL19207269 | 0.84 | EGLN2 (0.41) | — | |
| SCHEMBL19207327 | 0.84 | KDM2B (0.36) | RIPK1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL19207261 | 0.83 | KDM5A (0.38) | RIPK1LMNAMEN1KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411365-B1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-11-20 | — | — | EP | disclosed |
| WO-2017133990-A1 | PYRAZOL-PYRIDINE DERIVATIVES AS EAAT3 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-10 | — | — | WO | disclosed |